Tuthmosis the First was the son of Amenhotep the First, probably by one of his concubines. In order to legitimize his accession, he married his aunt, Ahmose, his father's sister.
In his conduct of foreign affairs, the Egyptian army reached during his reign, for the first time in history, the region of the Euphrates, where he sat up a boundary stela on the bank of the river.
Tuthmosis the First also led a campaign against Nubia as far south as the Third Cataract.
In architectural activities, his name was associated with the inauguration of the first stone works at Karnak, where he transformed the early sanctuary into a true temple.
He built the Fourth Pylon, which was preceded by two granite obelisks. Behind this pylon, he added a vast hypostyle hall that was roofed in timber and supported by columns.
Behind this hall, the king built the Fifth Pylon and the open court behind it, which was surrounded by a colonnade.
Tuthmosis the First was the first pharaoh to have his tomb cut in the Valley of the Kings. The mummy of this king was found in the Deir el-Bahari cache.